8 Ultimately, furosemide increases the urine output by the kidney. 9 It works directly acts on the cells of the nephron and indirectly modifies the content of the renal filtrate. Furosemide is a potent loop diuretic that works to increase the excretion of Na+ and water by the kidneys by inhibiting their reabsorption from the proximal and distal tubules, as well as the loop of Henle. 9 Type Small Molecule Groups Approved, Vet approved Structureįurosemide manages hypertension and edema associated with congestive heart failure, cirrhosis, and renal disease, including the nephrotic syndrome. In addition to oral formulations, the solution for intravenous and intramuscular administration is also available, which is typically limited to patients who are unable to take oral medication or for patients in emergency clinical situations. 1 The use of furosemide is particularly beneficial in clinical settings that require a drug with a higher diuretic potential. Furosemide has a fast onset and short duration of action and has been used safely and effectively in both pediatric and adult patients. 10 It mainly works by inhibiting electrolyte reabsorption from the kidneys and enhancing the excretion of water from the body. 9 Furosemide is used for edema secondary to various clinical conditions, such as congestive heart failure exacerbation, liver failure, renal failure, and high blood pressure. Lasix Generic Name Furosemide DrugBank Accession Number DB00695 Backgroundįurosemide is a potent loop diuretic that acts on the kidneys to ultimately increase water loss from the body.
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